<?xml version="1.0" encoding="utf-8"?>
<!--DFS XBRL Instance Document - http://www.dfsco.com/financial-services/ - Version R3.0 - on 19-March-2019 [01:19:40] {AM}-->
<schema targetNamespace="http://organogenesis.com/20181231" elementFormDefault="qualified" xmlns:orgo="http://organogenesis.com/20181231" xmlns="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xl="http://www.xbrl.org/2003/XLink" xmlns:us-gaap="http://fasb.org/us-gaap/2018-01-31" xmlns:country="http://xbrl.sec.gov/country/2017-01-31" xmlns:currency="http://xbrl.sec.gov/currency/2017-01-31" xmlns:dei="http://xbrl.sec.gov/dei/2018-01-31" xmlns:exch="http://xbrl.sec.gov/exch/2018-01-31" xmlns:invest="http://xbrl.sec.gov/invest/2013-01-31" xmlns:naics="http://xbrl.sec.gov/naics/2017-01-31" xmlns:sic="http://xbrl.sec.gov/sic/2011-01-31" xmlns:us-types="http://fasb.org/us-types/2018-01-31" xmlns:stpr="http://xbrl.sec.gov/stpr/2018-01-31" xmlns:deprecated="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:srt="http://fasb.org/srt/2018-01-31">
<annotation>
<appinfo>
<link:roleType roleURI="http://organogenesis.com/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
<link:definition>1001 - Document - Document and Entity Information</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ConsolidatedBalanceSheets" id="ConsolidatedBalanceSheets">
<link:definition>1002 - Statement - CONSOLIDATED BALANCE SHEETS</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ConsolidatedBalanceSheetsParenthetical" id="ConsolidatedBalanceSheetsParenthetical">
<link:definition>1003 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ConsolidatedStatementsOfOperations" id="ConsolidatedStatementsOfOperations">
<link:definition>1004 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ConsolidatedStatementsOfRedeemableCommonStockAndStockholdersEquityDeficit" id="ConsolidatedStatementsOfRedeemableCommonStockAndStockholdersEquityDeficit">
<link:definition>1005 - Statement - CONSOLIDATED STATEMENTS OF REDEEMABLE COMMON STOCK AND STOCKHOLDERS' EQUITY (DEFICIT)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ConsolidatedStatementsOfRedeemableCommonStockAndStockholdersEquityDeficitParenthetical" id="ConsolidatedStatementsOfRedeemableCommonStockAndStockholdersEquityDeficitParenthetical">
<link:definition>1006 - Statement - CONSOLIDATED STATEMENTS OF REDEEMABLE COMMON STOCK AND STOCKHOLDERS' EQUITY (DEFICIT) (Parenthetical)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ConsolidatedStatementsOfCashFlows" id="ConsolidatedStatementsOfCashFlows">
<link:definition>1007 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/NatureOfBusiness" id="NatureOfBusiness">
<link:definition>1008 - Disclosure - Nature of Business</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/SignificantAccountingPolicies" id="SignificantAccountingPolicies">
<link:definition>1009 - Disclosure - Significant Accounting Policies</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ReverseAcquisitionWithAvistaAndOrganogenesis" id="ReverseAcquisitionWithAvistaAndOrganogenesis">
<link:definition>1010 - Disclosure - Reverse Acquisition with Avista and Organogenesis</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/RealEstateEntities" id="RealEstateEntities">
<link:definition>1011 - Disclosure - Real Estate Entities</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AcquisitionOfNutechMedical" id="AcquisitionOfNutechMedical">
<link:definition>1012 - Disclosure - Acquisition of NuTech Medical</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/FairValueMeasurementOfFinancialInstruments" id="FairValueMeasurementOfFinancialInstruments">
<link:definition>1013 - Disclosure - Fair Value Measurement of Financial Instruments</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AccountsReceivableNet" id="AccountsReceivableNet">
<link:definition>1014 - Disclosure - Accounts receivable, net</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/Inventories" id="Inventories">
<link:definition>1015 - Disclosure - Inventories</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/PrepaidExpensesAndOtherCurrentAssets" id="PrepaidExpensesAndOtherCurrentAssets">
<link:definition>1016 - Disclosure - Prepaid Expenses and Other Current Assets</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/PropertyAndEquipment" id="PropertyAndEquipment">
<link:definition>1017 - Disclosure - Property and Equipment</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/NotesReceivableRelatedParties" id="NotesReceivableRelatedParties">
<link:definition>1018 - Disclosure - Notes Receivable - Related Parties</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/GoodwillAndIntangibleAssets" id="GoodwillAndIntangibleAssets">
<link:definition>1019 - Disclosure - Goodwill and Intangible Assets</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AccruedExpensesAndOtherCurrentLiabilities" id="AccruedExpensesAndOtherCurrentLiabilities">
<link:definition>1020 - Disclosure - Accrued Expenses and Other Current Liabilities</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/LongTermDebtAffiliates" id="LongTermDebtAffiliates">
<link:definition>1021 - Disclosure - Long-Term Debt - Affiliates</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/LineOfCreditAndNotesPayable" id="LineOfCreditAndNotesPayable">
<link:definition>1022 - Disclosure - Line of Credit and Notes Payable</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/CapitalizedLeases" id="CapitalizedLeases">
<link:definition>1023 - Disclosure - Capitalized Leases</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/StockholdersEquity" id="StockholdersEquity">
<link:definition>1024 - Disclosure - Stockholders' Equity</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/Warrants" id="Warrants">
<link:definition>1025 - Disclosure - Warrants</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/StockOptions" id="StockOptions">
<link:definition>1026 - Disclosure - Stock Options</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/Royalties" id="Royalties">
<link:definition>1027 - Disclosure - Royalties</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/IncomeTaxes" id="IncomeTaxes">
<link:definition>1028 - Disclosure - Income Taxes</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/NetLossPerShare" id="NetLossPerShare">
<link:definition>1029 - Disclosure - Net Loss Per Share</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ProductAndGeographicSales" id="ProductAndGeographicSales">
<link:definition>1030 - Disclosure - Product and Geographic Sales</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/CommitmentsAndContingencies" id="CommitmentsAndContingencies">
<link:definition>1031 - Disclosure - Commitments and Contingencies</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/RelatedParties" id="RelatedParties">
<link:definition>1032 - Disclosure - Related Parties</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/EmployeeBenefitPlan" id="EmployeeBenefitPlan">
<link:definition>1033 - Disclosure - Employee Benefit Plan</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/SelectedQuarterlyFinancialInformationUnaudited" id="SelectedQuarterlyFinancialInformationUnaudited">
<link:definition>1034 - Disclosure - Selected Quarterly Financial Information (Unaudited)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/SubsequentEvents" id="SubsequentEvents">
<link:definition>1035 - Disclosure - Subsequent Events</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/SignificantAccountingPoliciesPolicies" id="SignificantAccountingPoliciesPolicies">
<link:definition>1036 - Disclosure - Significant Accounting Policies (Policies)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/SignificantAccountingPoliciesTables" id="SignificantAccountingPoliciesTables">
<link:definition>1037 - Disclosure - Significant Accounting Policies (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/RealEstateEntitiesTables" id="RealEstateEntitiesTables">
<link:definition>1038 - Disclosure - Real Estate Entities (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AcquisitionOfNutechMedicalTables" id="AcquisitionOfNutechMedicalTables">
<link:definition>1039 - Disclosure - Acquisition of NuTech Medical (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/FairValueMeasurementOfFinancialInstrumentsTables" id="FairValueMeasurementOfFinancialInstrumentsTables">
<link:definition>1040 - Disclosure - Fair Value Measurement of Financial Instruments (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AccountsReceivableNetTables" id="AccountsReceivableNetTables">
<link:definition>1041 - Disclosure - Accounts receivable, net (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/InventoriesTables" id="InventoriesTables">
<link:definition>1042 - Disclosure - Inventories (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/PrepaidExpensesAndOtherCurrentAssetsTables" id="PrepaidExpensesAndOtherCurrentAssetsTables">
<link:definition>1043 - Disclosure - Prepaid Expenses and Other Current Assets (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/PropertyAndEquipmentTables" id="PropertyAndEquipmentTables">
<link:definition>1044 - Disclosure - Property and Equipment (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/NotesReceivableRelatedPartiesTables" id="NotesReceivableRelatedPartiesTables">
<link:definition>1045 - Disclosure - Notes Receivable - Related Parties (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/GoodwillAndIntangibleAssetsTables" id="GoodwillAndIntangibleAssetsTables">
<link:definition>1046 - Disclosure - Goodwill and Intangible Assets (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AccruedExpensesAndOtherCurrentLiabilitiesTables" id="AccruedExpensesAndOtherCurrentLiabilitiesTables">
<link:definition>1047 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/LongTermDebtAffiliatesTables" id="LongTermDebtAffiliatesTables">
<link:definition>1048 - Disclosure - Long-Term Debt - Affiliates (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/LineOfCreditAndNotesPayableTables" id="LineOfCreditAndNotesPayableTables">
<link:definition>1049 - Disclosure - Line of Credit and Notes Payable (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/CapitalizedLeasesTables" id="CapitalizedLeasesTables">
<link:definition>1050 - Disclosure - Capitalized Leases (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/WarrantsTables" id="WarrantsTables">
<link:definition>1051 - Disclosure - Warrants (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/StockOptionsTables" id="StockOptionsTables">
<link:definition>1052 - Disclosure - Stock Options (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/IncomeTaxesTables" id="IncomeTaxesTables">
<link:definition>1053 - Disclosure - Income Taxes (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/NetLossPerShareTables" id="NetLossPerShareTables">
<link:definition>1054 - Disclosure - Net Loss Per Share (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ProductAndGeographicSalesTables" id="ProductAndGeographicSalesTables">
<link:definition>1055 - Disclosure - Product and Geographic Sales (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/CommitmentsAndContingenciesTables" id="CommitmentsAndContingenciesTables">
<link:definition>1056 - Disclosure - Commitments and Contingencies (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/QuarterlyFinancialInformationUnauditedTables" id="QuarterlyFinancialInformationUnauditedTables">
<link:definition>1057 - Disclosure - Quarterly Financial Information (unaudited) (Tables)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/NatureOfBusinessAdditionalInformationDetail" id="NatureOfBusinessAdditionalInformationDetail">
<link:definition>1058 - Disclosure - Nature of Business - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/SignificantAccountingPoliciesPropertyPlantAndEquipmentDetail" id="SignificantAccountingPoliciesPropertyPlantAndEquipmentDetail">
<link:definition>1059 - Disclosure - Significant Accounting Policies - Property, Plant and Equipment (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/SignificantAccountingPoliciesScheduleOfFiniteLivedIntangibleAssetsDetail" id="SignificantAccountingPoliciesScheduleOfFiniteLivedIntangibleAssetsDetail">
<link:definition>1060 - Disclosure - Significant Accounting Policies -Schedule of Finite-Lived Intangible Assets (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/SignificantAccountingPoliciesAdditionalInformationDetail" id="SignificantAccountingPoliciesAdditionalInformationDetail">
<link:definition>1061 - Disclosure - Significant Accounting Policies - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ReverseAcquisitionWithAvistaAndOrganogenesisAdditionalInformationDetail" id="ReverseAcquisitionWithAvistaAndOrganogenesisAdditionalInformationDetail">
<link:definition>1062 - Disclosure - Reverse Acquisition with Avista and Organogenesis - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/RealEstateEntitiesDetail" id="RealEstateEntitiesDetail">
<link:definition>1063 - Disclosure - Real Estate Entities (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AcquisitionOfNutechMedicalFairValuesOfTheAssetsAcquiredAndLiabilitiesAssumedDetail" id="AcquisitionOfNutechMedicalFairValuesOfTheAssetsAcquiredAndLiabilitiesAssumedDetail">
<link:definition>1064 - Disclosure - Acquisition of NuTech Medical - Fair Values of the Assets Acquired and Liabilities Assumed  (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AcquisitionOfNutechMedicalProFormaStatementsOfOperationsDetail" id="AcquisitionOfNutechMedicalProFormaStatementsOfOperationsDetail">
<link:definition>1065 - Disclosure - Acquisition of NuTech Medical - Pro Forma Statements of Operations (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AcquisitionOfNutechMedicalAdditionalInformationDetail" id="AcquisitionOfNutechMedicalAdditionalInformationDetail">
<link:definition>1066 - Disclosure - Acquisition of NuTech Medical - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/FairValueMeasurementOfFinancialInstrumentsFinancialAssetsAndLiabilitiesMeasuredAtFairValueDetail" id="FairValueMeasurementOfFinancialInstrumentsFinancialAssetsAndLiabilitiesMeasuredAtFairValueDetail">
<link:definition>1067 - Disclosure - Fair Value Measurement of Financial Instruments - Financial Assets And Liabilities Measured At Fair Value (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/FairValueMeasurementOfFinancialInstrumentsAggregateFairValueOfWarrantLiabilityDetail" id="FairValueMeasurementOfFinancialInstrumentsAggregateFairValueOfWarrantLiabilityDetail">
<link:definition>1068 - Disclosure - Fair Value Measurement of Financial Instruments - Aggregate Fair Value Of Warrant Liability (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/FairValueMeasurementOfFinancialInstrumentsAdditionalInformationDetail" id="FairValueMeasurementOfFinancialInstrumentsAdditionalInformationDetail">
<link:definition>1069 - Disclosure - Fair Value Measurement of Financial Instruments - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AccountsReceivableNetDetail" id="AccountsReceivableNetDetail">
<link:definition>1070 - Disclosure - Accounts receivable, net (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AccountsReceivableNetSalesReturnsAndDoubtfulAccountsDetail" id="AccountsReceivableNetSalesReturnsAndDoubtfulAccountsDetail">
<link:definition>1071 - Disclosure - Accounts receivable, net - Sales Returns and Doubtful Accounts (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/InventoriesDetail" id="InventoriesDetail">
<link:definition>1072 - Disclosure - Inventories (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/InventoriesAdditionalInformationDetail" id="InventoriesAdditionalInformationDetail">
<link:definition>1073 - Disclosure - Inventories - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/PrepaidExpensesAndOtherCurrentAssetsDetail" id="PrepaidExpensesAndOtherCurrentAssetsDetail">
<link:definition>1074 - Disclosure - Prepaid Expenses and Other Current Assets (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/PropertyAndEquipmentDetail" id="PropertyAndEquipmentDetail">
<link:definition>1075 - Disclosure - Property and Equipment (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/PropertyAndEquipmentAdditionalInformationDetail" id="PropertyAndEquipmentAdditionalInformationDetail">
<link:definition>1076 - Disclosure - Property and Equipment - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/NotesReceivableRelatedPartiesDetail" id="NotesReceivableRelatedPartiesDetail">
<link:definition>1077 - Disclosure - Notes Receivable - Related Parties (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/NotesReceivableRelatedPartiesAdditionalInformationDetail" id="NotesReceivableRelatedPartiesAdditionalInformationDetail">
<link:definition>1078 - Disclosure - Notes Receivable - Related Parties - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/GoodwillAndIntangibleAssetsIdentifiableIntangibleAssetsDetail" id="GoodwillAndIntangibleAssetsIdentifiableIntangibleAssetsDetail">
<link:definition>1079 - Disclosure - Goodwill and Intangible Assets - Identifiable intangible assets (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/GoodwillAndIntangibleAssetsEstimatedFutureAnnualAmortizationExpenseDetail" id="GoodwillAndIntangibleAssetsEstimatedFutureAnnualAmortizationExpenseDetail">
<link:definition>1080 - Disclosure - Goodwill and Intangible Assets - Estimated future annual amortization expense (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/GoodwillAndIntangibleAssetsAdditionalInformationDetail" id="GoodwillAndIntangibleAssetsAdditionalInformationDetail">
<link:definition>1081 - Disclosure - Goodwill and Intangible Assets - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/AccruedExpensesAndOtherCurrentLiabilitiesDetail" id="AccruedExpensesAndOtherCurrentLiabilitiesDetail">
<link:definition>1082 - Disclosure - Accrued Expenses and Other Current Liabilities (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/LongTermDebtAffiliatesLongTermDebtPayableDetail" id="LongTermDebtAffiliatesLongTermDebtPayableDetail">
<link:definition>1083 - Disclosure - Long-Term Debt - Affiliates - Long-term debt payable (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/LongTermDebtAffiliatesDueToAffiliatesDetails" id="LongTermDebtAffiliatesDueToAffiliatesDetails">
<link:definition>1084 - Disclosure - Long-Term Debt - Affiliates - Due to affiliates (Details)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/LongTermDebtAffiliatesAdditionalInformationDetail" id="LongTermDebtAffiliatesAdditionalInformationDetail">
<link:definition>1085 - Disclosure - Long-Term Debt - Affiliates - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/LineOfCreditAndNotesPayableDetail" id="LineOfCreditAndNotesPayableDetail">
<link:definition>1086 - Disclosure - Line of Credit and Notes Payable (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/LineOfCreditAndNotesPayableFuturePaymentsOfNotesPayableDetail" id="LineOfCreditAndNotesPayableFuturePaymentsOfNotesPayableDetail">
<link:definition>1087 - Disclosure - Line of Credit and Notes Payable - Future payments of notes payable (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/LineOfCreditAndNotesPayableAdditionalInformationDetail" id="LineOfCreditAndNotesPayableAdditionalInformationDetail">
<link:definition>1088 - Disclosure - Line of Credit and Notes Payable - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/CapitalizedLeasesFutureLeasePaymentsDetail" id="CapitalizedLeasesFutureLeasePaymentsDetail">
<link:definition>1089 - Disclosure - Capitalized Leases - Future Lease Payments (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/CapitalizedLeasesAdditionalInformationDetail" id="CapitalizedLeasesAdditionalInformationDetail">
<link:definition>1090 - Disclosure - Capitalized Leases - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/StockholdersEquityAdditionalInformationDetail" id="StockholdersEquityAdditionalInformationDetail">
<link:definition>1091 - Disclosure - Stockholders Equity - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/WarrantsScheduleOfOutstandingWarrantsToPurchaseCommonStockDetail" id="WarrantsScheduleOfOutstandingWarrantsToPurchaseCommonStockDetail">
<link:definition>1092 - Disclosure - Warrants - Schedule of Outstanding Warrants to Purchase Common Stock (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/WarrantsAdditionalInformationDetail" id="WarrantsAdditionalInformationDetail">
<link:definition>1093 - Disclosure - Warrants - Additional information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/StockOptionsAdditionalInformationDetail" id="StockOptionsAdditionalInformationDetail">
<link:definition>1094 - Disclosure - Stock Options - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/StockOptionsScheduleOfFairValueOfStockOptionsGrantedToEmployeesAndDirectorsDetail" id="StockOptionsScheduleOfFairValueOfStockOptionsGrantedToEmployeesAndDirectorsDetail">
<link:definition>1095 - Disclosure - Stock Options - Schedule of Fair Value of Stock Options Granted to Employees and Directors (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/StockOptionsSummaryOfStockOptionActivityDetail" id="StockOptionsSummaryOfStockOptionActivityDetail">
<link:definition>1096 - Disclosure - Stock Options - Summary of Stock Option Activity (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/RoyaltiesAdditionalInformationDetail" id="RoyaltiesAdditionalInformationDetail">
<link:definition>1097 - Disclosure - Royalties - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/IncomeTaxesAdditionalInformationDetail" id="IncomeTaxesAdditionalInformationDetail">
<link:definition>1098 - Disclosure - Income Taxes - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/IncomeTaxesScheduleOfComponentsOfIncomeTaxExpenseBenefitDetail" id="IncomeTaxesScheduleOfComponentsOfIncomeTaxExpenseBenefitDetail">
<link:definition>1099 - Disclosure - Income Taxes - Schedule of Components of Income Tax Expense (Benefit) (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/IncomeTaxesComponentOfCompanysDeferredTaxAssetsAndLiabilitiesDetail" id="IncomeTaxesComponentOfCompanysDeferredTaxAssetsAndLiabilitiesDetail">
<link:definition>1100 - Disclosure - Income Taxes - Component of Company's Deferred Tax Assets and Liabilities (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/IncomeTaxesScheduleOfEffectiveIncomeTaxRateReconciliationDetail" id="IncomeTaxesScheduleOfEffectiveIncomeTaxRateReconciliationDetail">
<link:definition>1101 - Disclosure - Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/IncomeTaxesScheduleOfUnrecognizedTaxBenefitsRollForwardDetail" id="IncomeTaxesScheduleOfUnrecognizedTaxBenefitsRollForwardDetail">
<link:definition>1102 - Disclosure - Income Taxes - Schedule of Unrecognized Tax Benefits Roll Forward (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/NetLossPerShareBasicAndDilutedNetLossPerShareDetail" id="NetLossPerShareBasicAndDilutedNetLossPerShareDetail">
<link:definition>1103 - Disclosure - Net Loss Per Share - Basic and diluted net loss per share (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/NetLossPerShareScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetail" id="NetLossPerShareScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareDetail">
<link:definition>1104 - Disclosure - Net Loss Per Share - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ProductAndGeographicSalesScheduleOfRevenueByProductCategoryDetail" id="ProductAndGeographicSalesScheduleOfRevenueByProductCategoryDetail">
<link:definition>1105 - Disclosure - Product and Geographic Sales - Schedule of Revenue by Product Category (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/ProductAndGeographicSalesAdditionalInformationDetail" id="ProductAndGeographicSalesAdditionalInformationDetail">
<link:definition>1106 - Disclosure - Product and Geographic Sales - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/CommitmentsAndContingenciesScheduleOfOperatingLeasedAssetsDetail" id="CommitmentsAndContingenciesScheduleOfOperatingLeasedAssetsDetail">
<link:definition>1107 - Disclosure - Commitments and Contingencies (Schedule Of Operating Leased Assets) (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/CommitmentsAndContingenciesAdditionalInformationDetail" id="CommitmentsAndContingenciesAdditionalInformationDetail">
<link:definition>1108 - Disclosure - Commitments and Contingencies - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/RelatedPartyAdditionalInformationDetail" id="RelatedPartyAdditionalInformationDetail">
<link:definition>1109 - Disclosure - Related Party-Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/EmployeeBenefitPlanAdditionalInformationDetail" id="EmployeeBenefitPlanAdditionalInformationDetail">
<link:definition>1110 - Disclosure - Employee Benefit Plan - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/QuarterlyFinancialInformationUnauditedDetails" id="QuarterlyFinancialInformationUnauditedDetails">
<link:definition>1111 - Disclosure - Quarterly Financial Information (unaudited) (Details)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://organogenesis.com/role/SubsequentEventsAdditionalInformationDetail" id="SubsequentEventsAdditionalInformationDetail">
<link:definition>1112 - Disclosure - Subsequent Events - Additional Information (Detail)</link:definition>
<link:usedOn>link:presentationLink</link:usedOn>
<link:usedOn>link:definitionLink</link:usedOn>
<link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:linkbaseRef xlink:type="simple" xlink:href="orgo-20181231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
<link:linkbaseRef xlink:type="simple" xlink:href="orgo-20181231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
<link:linkbaseRef xlink:type="simple" xlink:href="orgo-20181231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
<link:linkbaseRef xlink:type="simple" xlink:href="orgo-20181231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
</appinfo>
</annotation>
<import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
<import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" />
<import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
<import namespace="http://fasb.org/us-gaap/2018-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/invest/2013-01-31" schemaLocation="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/country/2017-01-31" schemaLocation="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/currency/2017-01-31" schemaLocation="http://xbrl.sec.gov/currency/2017/currency-2017-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/exch/2018-01-31" schemaLocation="https://xbrl.sec.gov/exch/2018/exch-2018-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/naics/2017-01-31" schemaLocation="http://xbrl.sec.gov/naics/2017/naics-2017-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/stpr/2018-01-31" schemaLocation="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd" />
<import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
<import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />
<import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd" />
<import namespace="http://xbrl.sec.gov/dei/2018-01-31" schemaLocation="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd" />
<import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />
<import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
<import namespace="http://fasb.org/us-types/2018-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2018/elts/us-types-2018-01-31.xsd" />
<import namespace="http://fasb.org/srt/2018-01-31" schemaLocation="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd" />
<element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_DocumentAndEntityInformationAbstract" substitutionGroup="xbrli:item" />
<element name="AccruedExpensesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_AccruedExpensesAndOtherCurrentLiabilities" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="RedeemableCommonStockLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_RedeemableCommonStockLiability" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="WarrantLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_WarrantLiability" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ChangeInFairValueOfWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ChangeInFairValueOfWarrants" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="WriteOffOfDeferredOfferingCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_WriteOffOfDeferredOfferingCosts" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="StockIssuedDuringPeriodValueWarrantExercise" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_StockIssuedDuringPeriodValueWarrantExercise" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="StockIssuedDuringPeriodShareWarrantExercise" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_StockIssuedDuringPeriodShareWarrantExercise" substitutionGroup="xbrli:item" />
<element name="StockIssuedDuringPeriodValueExtinguishmentOfDebt" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_StockIssuedDuringPeriodValueExtinguishmentOfDebt" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="StockIssuedDuringPeriodSharesExtinguishmentOfDebt" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_StockIssuedDuringPeriodSharesExtinguishmentOfDebt" substitutionGroup="xbrli:item" />
<element name="StockIssuedDuringPeriodValueExerciseOfPutOption" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_StockIssuedDuringPeriodValueExerciseOfPutOption" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AdjustmentsToAdditionalPaidInCapitalExtinguishmentOfDebt" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_AdjustmentsToAdditionalPaidInCapitalExtinguishmentOfDebt" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AdjustmentsToAdditionalPaidInCapitalRecapitalizationCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_AdjustmentsToAdditionalPaidInCapitalRecapitalizationCost" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="RedeemableCommonStockMemberMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_RedeemableCommonStockMemberMember" substitutionGroup="xbrli:item" />
<element name="OfferingCosts" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_OfferingCosts" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="NonCashInterestExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NonCashInterestExpense" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="NonCashInterestIncome" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NonCashInterestIncome" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ImpairmentOfNotesReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ImpairmentOfNotesReceivable" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ProvisionForInventoryReserve" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ProvisionForInventoryReserve" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="FairValueAdjustmentOfInterestRateSwap" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_FairValueAdjustmentOfInterestRateSwap" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="FairValueAdjustmentOfForfeitureRights" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_FairValueAdjustmentOfForfeitureRights" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="VariableInterestEntityDeconsolidation" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_VariableInterestEntityDeconsolidation" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="IncreaseDecreaseInAccruedLiabilitiesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_IncreaseDecreaseInAccruedLiabilitiesAndOtherCurrentLiabilities" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="IncreaseDecreaseInAccruedInterestOfAffiliateDebt" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_IncreaseDecreaseInAccruedInterestOfAffiliateDebt" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ProceedsFromRepaymentsOfNotesPayableToRelatedParties" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ProceedsFromRepaymentsOfNotesPayableToRelatedParties" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ProceedsFromAffiliatesLongTermDebt" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ProceedsFromAffiliatesLongTermDebt" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="PaymentOfRecapitalizationCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_PaymentOfRecapitalizationCost" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="NonCashRentExpenseIncome" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NonCashRentExpenseIncome" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="NonCashGainOnInvestorDebtExtinguishment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NonCashGainOnInvestorDebtExtinguishment" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ExerciseOfPutOptionRedeemableCommonStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ExerciseOfPutOptionRedeemableCommonStock" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="SubordinatedNotesConvertedWarrantsIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_SubordinatedNotesConvertedWarrantsIssued" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="NotesPayableConvertedWarrantsIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NotesPayableConvertedWarrantsIssued" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="NonCashExtinguishmentOfSubordinatedNotesOfAffiliates" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NonCashExtinguishmentOfSubordinatedNotesOfAffiliates" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="NonCashAccretionOfRedeemableCommonStock" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NonCashAccretionOfRedeemableCommonStock" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="NonCashDeconsolidationOfVariableInterestEntities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NonCashDeconsolidationOfVariableInterestEntities" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="IssueOfDeferrdAcquisitionConsideration" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_IssueOfDeferrdAcquisitionConsideration" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="IssueOfContingentConsideration" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_IssueOfContingentConsideration" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="NonCashPurchaseOfPropertyPlantAndEquipment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NonCashPurchaseOfPropertyPlantAndEquipment" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DisclosureOfReverseAcquisitionWithAvistaAndOrganogenesisAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_DisclosureOfReverseAcquisitionWithAvistaAndOrganogenesisAbstract" substitutionGroup="xbrli:item" />
<element name="ReverseAcquisitionWithAvistaAndOrganogenesisTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ReverseAcquisitionWithAvistaAndOrganogenesisTextBlock" substitutionGroup="xbrli:item" />
<element name="PrepaidExpensesAndOtherCurrentAssetsTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_PrepaidExpensesAndOtherCurrentAssetsTextBlock" substitutionGroup="xbrli:item" />
<element name="NoteReceivableRelatedPartiesTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NoteReceivableRelatedPartiesTextBlock" substitutionGroup="xbrli:item" />
<element name="WarrantsDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_WarrantsDisclosureTextBlock" substitutionGroup="xbrli:item" />
<element name="RoyaltiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_RoyaltiesAbstract" substitutionGroup="xbrli:item" />
<element name="DisclosureOfRoyaltiesTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_DisclosureOfRoyaltiesTextBlock" substitutionGroup="xbrli:item" />
<element name="EmergingGrowthCompanyPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_EmergingGrowthCompanyPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="WarrantLiabilityPolicyTextBlockPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_WarrantLiabilityPolicyTextBlockPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="InterestIncomePolicyTextBlockPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_InterestIncomePolicyTextBlockPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="MedicalDeviceExciseTaxPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_MedicalDeviceExciseTaxPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="RecentlyAdoptedAccountingPronouncementsPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_RecentlyAdoptedAccountingPronouncementsPolicyTextBlock" substitutionGroup="xbrli:item" />
<element name="SummaryOfEstimatedUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_SummaryOfEstimatedUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock" substitutionGroup="xbrli:item" />
<element name="InvestmentsInAndAdvancesFromAffiliatesTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_InvestmentsInAndAdvancesFromAffiliatesTableTextBlock" substitutionGroup="xbrli:item" />
<element name="ScheduleOfMaturitiesOfLongTermsDebtTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ScheduleOfMaturitiesOfLongTermsDebtTableTextBlock" substitutionGroup="xbrli:item" />
<element name="ScheduleOfOperatingLeasedAssetsTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ScheduleOfOperatingLeasedAssetsTableTextBlock" substitutionGroup="xbrli:item" />
<element name="RedeemableCommonStockMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_RedeemableCommonStockMember" substitutionGroup="xbrli:item" />
<element name="SubordinatedDebtPrincipalRepayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_SubordinatedDebtPrincipalRepayment" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="SubordinatedDebtAccruedInterestAndLoanFeePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_SubordinatedDebtAccruedInterestAndLoanFeePayment" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="WorkingCapital" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_WorkingCapital" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="NuTechMedicalMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_NuTechMedicalMember" substitutionGroup="xbrli:item" />
<element name="AvistaMergerSubMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AvistaMergerSubMember" substitutionGroup="xbrli:item" />
<element name="PipeInvestorMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_PipeInvestorMember" substitutionGroup="xbrli:item" />
<element name="OrganogenesisIncMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_OrganogenesisIncMember" substitutionGroup="xbrli:item" />
<element name="SignificantAccountingPoliciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_SignificantAccountingPoliciesTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="SignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_SignificantAccountingPoliciesLineItems" substitutionGroup="xbrli:item" />
<element name="WriteOffOfDeferredOfferingCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_WriteOffOfDeferredOfferingCost" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="LongTermDebtDueToAffiliatesFairValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_LongTermDebtDueToAffiliatesFairValue" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="ExciseTaxPercent" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ExciseTaxPercent" substitutionGroup="xbrli:item" />
<element name="DisclosureOfReverseAcquisitionWithAvistaAndOrganogenesisTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_DisclosureOfReverseAcquisitionWithAvistaAndOrganogenesisTable" substitutionGroup="xbrldt:hypercubeItem" />
<element name="AHPACMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AHPACMember" substitutionGroup="xbrli:item" />
<element name="DisclosureOfReverseAcquisitionWithAvistaAndOrganogenesisLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_DisclosureOfReverseAcquisitionWithAvistaAndOrganogenesisLineItems" substitutionGroup="xbrli:item" />
<element name="NumberOfFounderSharesDomesticated" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_NumberOfFounderSharesDomesticated" substitutionGroup="xbrli:item" />
<element name="CommonStockConsiderationTransferredUponSharesSurrender" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_CommonStockConsiderationTransferredUponSharesSurrender" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CommonStockSharesAgreedToSurrenderInWhichSharesWereCanceledWithMergerAgreementExecution" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_CommonStockSharesAgreedToSurrenderInWhichSharesWereCanceledWithMergerAgreementExecution" substitutionGroup="xbrli:item" />
<element name="CommonStockSharesAgreedToSurrenderSubjectedToSatisfactionOrWaiverOfCertainClosingConditions" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_CommonStockSharesAgreedToSurrenderSubjectedToSatisfactionOrWaiverOfCertainClosingConditions" substitutionGroup="xbrli:item" />
<element name="ClassOfWarrantOrRightNumberOfWarrantsOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ClassOfWarrantOrRightNumberOfWarrantsOutstanding" substitutionGroup="xbrli:item" />
<element name="AvistaMergerMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AvistaMergerMember" substitutionGroup="xbrli:item" />
<element name="AvistaHealthcarePublicAcquisitionCorpMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AvistaHealthcarePublicAcquisitionCorpMember" substitutionGroup="xbrli:item" />
<element name="FounderSharesTransactionsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_FounderSharesTransactionsMember" substitutionGroup="xbrli:item" />
<element name="PrivatePlacementWarrantsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_PrivatePlacementWarrantsMember" substitutionGroup="xbrli:item" />
<element name="SponsorAndOtherHoldersMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_SponsorAndOtherHoldersMember" substitutionGroup="xbrli:item" />
<element name="InitialShareholdersAndOtherHoldersMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_InitialShareholdersAndOtherHoldersMember" substitutionGroup="xbrli:item" />
<element name="VariableInterestEntityNonconsolidatedAccumulatedDeficit" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_VariableInterestEntityNonconsolidatedAccumulatedDeficit" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="VariableInterestEntityNonconsolidatedConsiderationTransferred" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_VariableInterestEntityNonconsolidatedConsiderationTransferred" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CashMemberMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_CashMemberMember" substitutionGroup="xbrli:item" />
<element name="DueFromAffiliatesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_DueFromAffiliatesMember" substitutionGroup="xbrli:item" />
<element name="PropertyAndEquipmentMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_PropertyAndEquipmentMember" substitutionGroup="xbrli:item" />
<element name="AccruedExpensesAndOtherCurrentLiabilitiesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AccruedExpensesAndOtherCurrentLiabilitiesMember" substitutionGroup="xbrli:item" />
<element name="NotesPayableMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_NotesPayableMember" substitutionGroup="xbrli:item" />
<element name="LiabilitiesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_LiabilitiesMember" substitutionGroup="xbrli:item" />
<element name="CurrentAssetsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_CurrentAssetsMember" substitutionGroup="xbrli:item" />
<element name="DanRoadAssociatesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_DanRoadAssociatesMember" substitutionGroup="xbrli:item" />
<element name="EightyfiveDanRoadAssociatesMemberMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_EightyfiveDanRoadAssociatesMemberMember" substitutionGroup="xbrli:item" />
<element name="SixtyfiveDanRoadAssociatesMemberMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_SixtyfiveDanRoadAssociatesMemberMember" substitutionGroup="xbrli:item" />
<element name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccruedExpensesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccruedExpensesAndOtherCurrentLiabilities" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationConsiderationTransferredRedeemableCommonStockIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_BusinessCombinationConsiderationTransferredRedeemableCommonStockIssued" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationConsiderationTransferredRestrictedCommonStockIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_BusinessCombinationConsiderationTransferredRestrictedCommonStockIssued" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationConsiderationTransferredStockOptionsIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_BusinessCombinationConsiderationTransferredStockOptionsIssued" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationContingentConsiderationWorkingCapitalAdjustments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_BusinessCombinationContingentConsiderationWorkingCapitalAdjustments" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationConsiderationTransferredRestrictedSharesForfeitureRightAsset" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_BusinessCombinationConsiderationTransferredRestrictedSharesForfeitureRightAsset" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationConsiderationTransferredCommonStockTransferred" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_BusinessCombinationConsiderationTransferredCommonStockTransferred" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationConsiderationTransferredDeferredAcquisitionConsiderationNetOfWorkingCapitalAdjustments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_BusinessCombinationConsiderationTransferredDeferredAcquisitionConsiderationNetOfWorkingCapitalAdjustments" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationConsiderationTransferredCommonStockIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_BusinessCombinationConsiderationTransferredCommonStockIssued" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="RestrictedSharesForfeitureRightAsset" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_RestrictedSharesForfeitureRightAsset" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationContingentConsiderationLiabilityInterestRate" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_BusinessCombinationContingentConsiderationLiabilityInterestRate" substitutionGroup="xbrli:item" />
<element name="BusinessCombinationContingentConsiderationQuarterlyPayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_BusinessCombinationContingentConsiderationQuarterlyPayments" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationContingentConsiderationFinalPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_BusinessCombinationContingentConsiderationFinalPayment" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationContingentConsiderationLiabilityMeasurementTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_BusinessCombinationContingentConsiderationLiabilityMeasurementTerm" substitutionGroup="xbrli:item" />
<element name="ContingentPurchaseEarnoutMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_ContingentPurchaseEarnoutMember" substitutionGroup="xbrli:item" />
<element name="ContingentConsiderationForfeitureRightsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_ContingentConsiderationForfeitureRightsMember" substitutionGroup="xbrli:item" />
<element name="RedeemableCommonStockLiabilityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_RedeemableCommonStockLiabilityMember" substitutionGroup="xbrli:item" />
<element name="ChangesInFairValueOfUnderlyingSharesPercentage" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ChangesInFairValueOfUnderlyingSharesPercentage" substitutionGroup="xbrli:item" />
<element name="ForfeitureRightsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_ForfeitureRightsMember" substitutionGroup="xbrli:item" />
<element name="AvistaMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AvistaMember" substitutionGroup="xbrli:item" />
<element name="DermagraftMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_DermagraftMember" substitutionGroup="xbrli:item" />
<element name="AllowanceForDoubtfulAccountsReceivableWriteOffs1" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_AllowanceForDoubtfulAccountsReceivableWriteOffs1" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="InventoryReserveChargedToCostOfGoodsSold" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_InventoryReserveChargedToCostOfGoodsSold" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="PrepaidSubscription" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_PrepaidSubscription" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="AccruedInterestNotesReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_AccruedInterestNotesReceivable" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ImpairmentOnNotesReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ImpairmentOnNotesReceivable" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ImpairmentOfEmployerLoan" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ImpairmentOfEmployerLoan" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="BonusPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_BonusPayment" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DeemedUncollectibleLoan" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_DeemedUncollectibleLoan" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AccruedInterestRatePercentage" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_AccruedInterestRatePercentage" substitutionGroup="xbrli:item" />
<element name="LiquidityLoanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_LiquidityLoanMember" substitutionGroup="xbrli:item" />
<element name="LiquidityLoanToOneFormerEmployeeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_LiquidityLoanToOneFormerEmployeeMember" substitutionGroup="xbrli:item" />
<element name="FormerCEOLiquidityLoansMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_FormerCEOLiquidityLoansMember" substitutionGroup="xbrli:item" />
<element name="CurrentCEOLiquidityLoansMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_CurrentCEOLiquidityLoansMember" substitutionGroup="xbrli:item" />
<element name="AccruedInterestMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AccruedInterestMember" substitutionGroup="xbrli:item" />
<element name="OptionLoanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_OptionLoanMember" substitutionGroup="xbrli:item" />
<element name="AvistaMergerAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AvistaMergerAgreementMember" substitutionGroup="xbrli:item" />
<element name="IndependentSalesAgencyNetworkMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_IndependentSalesAgencyNetworkMember" substitutionGroup="xbrli:item" />
<element name="BusinessCombinationContingentConsiderationLiabilityAccruedInterest" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_BusinessCombinationContingentConsiderationLiabilityAccruedInterest" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="TwoThousandTenLoansMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TwoThousandTenLoansMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandFifteenLoanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TwoThousandFifteenLoanMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandSixteenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TwoThousandSixteenMember" substitutionGroup="xbrli:item" />
<element name="SixtyFiveDanRoadSPEMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_SixtyFiveDanRoadSPEMember" substitutionGroup="xbrli:item" />
<element name="EightyFiveDanRoadAssociatesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_EightyFiveDanRoadAssociatesMember" substitutionGroup="xbrli:item" />
<element name="TwoSevenFiveDanRoadSPEMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TwoSevenFiveDanRoadSPEMember" substitutionGroup="xbrli:item" />
<element name="InterestRateOnTheUnPaidFee" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_InterestRateOnTheUnPaidFee" substitutionGroup="xbrli:item" />
<element name="ExtinguishmentOfDebtUnamorizedDiscountAmortizedToInterestExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ExtinguishmentOfDebtUnamorizedDiscountAmortizedToInterestExpense" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="LossOnUnamortizedDebtDiscount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_LossOnUnamortizedDebtDiscount" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="WriteOffOfUnamortizedDebtDiscount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_WriteOffOfUnamortizedDebtDiscount" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="RealEstateLoanPayableMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_RealEstateLoanPayableMember" substitutionGroup="xbrli:item" />
<element name="AdditionalFeeUnpaidMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AdditionalFeeUnpaidMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandTenAndTwoThousandFifteenLoansMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TwoThousandTenAndTwoThousandFifteenLoansMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandEighteenLoanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TwoThousandEighteenLoanMember" substitutionGroup="xbrli:item" />
<element name="AffiliateDebtPrincipalMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AffiliateDebtPrincipalMember" substitutionGroup="xbrli:item" />
<element name="AffiliateDebtInterestMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AffiliateDebtInterestMember" substitutionGroup="xbrli:item" />
<element name="NotesPayableDueInNextTwelveMonth" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_NotesPayableDueInNextTwelveMonth" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="NotesPayableDueInTwoYears" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_NotesPayableDueInTwoYears" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="NotesPayableDueInThreeYears" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_NotesPayableDueInThreeYears" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="NotesPayableDueInFourYears" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_NotesPayableDueInFourYears" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="PaidInKind" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_PaidInKind" substitutionGroup="xbrli:item" />
<element name="PercentageOfAccuredAndUnpaidInterestAndFees" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_PercentageOfAccuredAndUnpaidInterestAndFees" substitutionGroup="xbrli:item" />
<element name="PercentageOfPrepaymentFee" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_PercentageOfPrepaymentFee" substitutionGroup="xbrli:item" />
<element name="PercentageOfFinalPaymentFee" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_PercentageOfFinalPaymentFee" substitutionGroup="xbrli:item" />
<element name="WarrantsExercisableRelativelyFairValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_WarrantsExercisableRelativelyFairValue" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="OtherAssetsAmortizedValue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_OtherAssetsAmortizedValue" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="AccruedInterestDue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_AccruedInterestDue" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="EastwardFundLLCMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_EastwardFundLLCMember" substitutionGroup="xbrli:item" />
<element name="SubordinateMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_SubordinateMember" substitutionGroup="xbrli:item" />
<element name="TermLoanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TermLoanMember" substitutionGroup="xbrli:item" />
<element name="SVBMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_SVBMember" substitutionGroup="xbrli:item" />
<element name="AgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AgreementAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="AgreementDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AgreementDomain" substitutionGroup="xbrli:item" />
<element name="MLAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_MLAgreementMember" substitutionGroup="xbrli:item" />
<element name="CreditAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_CreditAgreementMember" substitutionGroup="xbrli:item" />
<element name="CapitalLeaseMonthlyRentalExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_CapitalLeaseMonthlyRentalExpense" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="LesseeCapitalLeaseRenewalTerm" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_LesseeCapitalLeaseRenewalTerm" substitutionGroup="xbrli:item" />
<element name="SixtyFiveDanRoadAssociatesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_SixtyFiveDanRoadAssociatesMember" substitutionGroup="xbrli:item" />
<element name="EightyFiveDanRoadAssociateMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_EightyFiveDanRoadAssociateMember" substitutionGroup="xbrli:item" />
<element name="PutOptionsExercisePricePriorToSecondAniversary" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_PutOptionsExercisePricePriorToSecondAniversary" substitutionGroup="xbrli:item" />
<element name="PutOptionsExercisePriceAtClosing" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_PutOptionsExercisePriceAtClosing" substitutionGroup="xbrli:item" />
<element name="PutOptionSharesBackPrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_PutOptionSharesBackPrice" substitutionGroup="xbrli:item" />
<element name="CurrentLiabilityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_CurrentLiabilityMember" substitutionGroup="xbrli:item" />
<element name="ClassOfWarrantOrRightExercisable" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ClassOfWarrantOrRightExercisable" substitutionGroup="xbrli:item" />
<element name="ClassOfWarrantOrRightsClassification" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ClassOfWarrantOrRightsClassification" substitutionGroup="xbrli:item" />
<element name="ClassOfWarrantOrRightsExpiration" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ClassOfWarrantOrRightsExpiration" substitutionGroup="xbrli:item" />
<element name="WarrantsOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_WarrantsOneMember" substitutionGroup="xbrli:item" />
<element name="WarrantsTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_WarrantsTwoMember" substitutionGroup="xbrli:item" />
<element name="WarrantsThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_WarrantsThreeMember" substitutionGroup="xbrli:item" />
<element name="WarrantsFourMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_WarrantsFourMember" substitutionGroup="xbrli:item" />
<element name="WarrantsFiveMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_WarrantsFiveMember" substitutionGroup="xbrli:item" />
<element name="WarrantsSixMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_WarrantsSixMember" substitutionGroup="xbrli:item" />
<element name="WarrantsSevenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_WarrantsSevenMember" substitutionGroup="xbrli:item" />
<element name="FairValueOfWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_FairValueOfWarrants" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="LossRecognisedOnFairValueOfWarrant" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_LossRecognisedOnFairValueOfWarrant" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="NumberOfSharesIssuesAsCollateralForSecuredDebt" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_NumberOfSharesIssuesAsCollateralForSecuredDebt" substitutionGroup="xbrli:item" />
<element name="TwoThousandEighteenStockIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TwoThousandEighteenStockIncentivePlanMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandThreeStockIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TwoThousandThreeStockIncentivePlanMember" substitutionGroup="xbrli:item" />
<element name="TwoThousandThreeAndTwoThousandEighteenStockIncentivePlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TwoThousandThreeAndTwoThousandEighteenStockIncentivePlanMember" substitutionGroup="xbrli:item" />
<element name="FairValueOfCommonShare" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_FairValueOfCommonShare" substitutionGroup="xbrli:item" />
<element name="MaintainanceCostOfUnderlyingPatents" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_MaintainanceCostOfUnderlyingPatents" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="AdditionalPaymentForMaintainanceCostOfPatents" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_AdditionalPaymentForMaintainanceCostOfPatents" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="ConsultingServiceAndRoyaltyPaymentTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_ConsultingServiceAndRoyaltyPaymentTerm" substitutionGroup="xbrli:item" />
<element name="AccruedExpenseMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AccruedExpenseMember" substitutionGroup="xbrli:item" />
<element name="LicenseAgreementOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_LicenseAgreementOneMember" substitutionGroup="xbrli:item" />
<element name="LicenseAgreementTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_LicenseAgreementTwoMember" substitutionGroup="xbrli:item" />
<element name="LicenseAgreementThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_LicenseAgreementThreeMember" substitutionGroup="xbrli:item" />
<element name="DisclosureOfIncomeTaxesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_DisclosureOfIncomeTaxesAbstract" substitutionGroup="xbrli:item" />
<element name="DescriptionOfRecognizedTaxBenefitsUponUltimateSettlement" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_DescriptionOfRecognizedTaxBenefitsUponUltimateSettlement" substitutionGroup="xbrli:item" />
<element name="OperatingLossCarryforwardsTaxCreditResearch" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_OperatingLossCarryforwardsTaxCreditResearch" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="DeferredTaxAssetReclassifiedAlternativeMinimumTaxPercentage" type="num:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_DeferredTaxAssetReclassifiedAlternativeMinimumTaxPercentage" substitutionGroup="xbrli:item" />
<element name="EffectiveIncomeTaxRateReconciliationUncertainTaxPositionReserves" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_EffectiveIncomeTaxRateReconciliationUncertainTaxPositionReserves" substitutionGroup="xbrli:item" />
<element name="EffectiveIncomeTaxRateReconciliationTaxReformAct" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_EffectiveIncomeTaxRateReconciliationTaxReformAct" substitutionGroup="xbrli:item" />
<element name="NetIncomeAvailableToCommonShareHoldersBasicAndDilutedAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_NetIncomeAvailableToCommonShareHoldersBasicAndDilutedAbstract" substitutionGroup="xbrli:item" />
<element name="NetIncomeLossAttributeToParent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_NetIncomeLossAttributeToParent" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="WeightedAverageNumberOfShareOutstandingBasicAndDilutedAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_WeightedAverageNumberOfShareOutstandingBasicAndDilutedAbstract" substitutionGroup="xbrli:item" />
<element name="DisclosureOfNetLossPerShareAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_DisclosureOfNetLossPerShareAbstract" substitutionGroup="xbrli:item" />
<element name="TemporaryEquityMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TemporaryEquityMember" substitutionGroup="xbrli:item" />
<element name="DisclosureOfProductAndGeographicSalesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_DisclosureOfProductAndGeographicSalesAbstract" substitutionGroup="xbrli:item" />
<element name="AdvancedWoundCareMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_AdvancedWoundCareMember" substitutionGroup="xbrli:item" />
<element name="SurgicalAndSportsMedicineMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_SurgicalAndSportsMedicineMember" substitutionGroup="xbrli:item" />
<element name="DeferredAcquisitionCostOutstanding" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_DeferredAcquisitionCostOutstanding" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationDeferredConsideration" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_BusinessCombinationDeferredConsideration" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AccruedLegalExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_AccruedLegalExpenses" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="BusinessCombinationConsiderationDeferred" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_BusinessCombinationConsiderationDeferred" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CapitalLeaseAmountOfMinimumRentalPaymentsIncreaseInEachYearInTenYearOptionToExtend" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_CapitalLeaseAmountOfMinimumRentalPaymentsIncreaseInEachYearInTenYearOptionToExtend" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="CapitalLeaseAmountOfMinimumRentalPaymentsIncreaseInEachYearInFiveYearOptionToExtend" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" id="orgo_CapitalLeaseAmountOfMinimumRentalPaymentsIncreaseInEachYearInFiveYearOptionToExtend" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="AdditionalPaymentInAggregateOfThePrincipalAmountPercentage" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_AdditionalPaymentInAggregateOfThePrincipalAmountPercentage" substitutionGroup="xbrli:item" />
<element name="LineOfCreditFacilityTerminationFeePercentage" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_LineOfCreditFacilityTerminationFeePercentage" substitutionGroup="xbrli:item" />
<element name="LineOfCreditFacilityTerminationFeeAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_LineOfCreditFacilityTerminationFeeAmount" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="LineOfCreditFacilityUnpaidPrincipalAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_LineOfCreditFacilityUnpaidPrincipalAmount" substitutionGroup="xbrli:item" xbrli:balance="credit" />
<element name="LineOfCreditFacilityEarlyTerminationPenalty" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_LineOfCreditFacilityEarlyTerminationPenalty" substitutionGroup="xbrli:item" xbrli:balance="debit" />
<element name="PercentageAvailableForRevolvingCommitments" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" id="orgo_PercentageAvailableForRevolvingCommitments" substitutionGroup="xbrli:item" />
<element name="TrancheOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TrancheOneMember" substitutionGroup="xbrli:item" />
<element name="TrancheTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TrancheTwoMember" substitutionGroup="xbrli:item" />
<element name="TrancheThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_TrancheThreeMember" substitutionGroup="xbrli:item" />
<element name="LoanAgreementMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_LoanAgreementMember" substitutionGroup="xbrli:item" />
<element name="LineOfCreditRepaymentAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_LineOfCreditRepaymentAxis" substitutionGroup="xbrldt:dimensionItem" />
<element name="LineOfCreditRepaymentDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_LineOfCreditRepaymentDomain" substitutionGroup="xbrli:item" />
<element name="RepaidBeforeOneYearMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_RepaidBeforeOneYearMember" substitutionGroup="xbrli:item" />
<element name="RepaidAfterOneYearBeforeTwoYearsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_RepaidAfterOneYearBeforeTwoYearsMember" substitutionGroup="xbrli:item" />
<element name="RepaidAfterTwoYearsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_RepaidAfterTwoYearsMember" substitutionGroup="xbrli:item" />
<element name="RepaymentThereafterMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" id="orgo_RepaymentThereafterMember" substitutionGroup="xbrli:item" />
</schema>
